Sam-E has a wide array of health benefits. Sam-e is beneficial for those suffering from psychiatric disorders such as depression. According to research studies, it acts as an immediate antidepressant, providing a sense of well being after consumption. Sam-e is also used to reduce pain symptoms associated with osteoarthritis, fibromyalgia, as it plays a role in stimulating production of glucosamine, a central compound used to reduce pain in joints. Women can also use Sam-E to relieve pain associated with premenstrual syndrome.